【摘要】 目的对肠道CT灌注成像方法及其在肠缺血诊断中的可能应用价值进行探讨。方法采用SIEMENS Sensation 16对12例实验动物于肠系膜上动脉栓塞前后进行灌注扫描。采用Dyn软件进行处理,得出兴趣区时间密度曲线,根据曲线计算灌注参数。对实验动物进行活检取材及病理学检查。结果所有实验动物均出现缺血改变。与正常肠管相比,缺血肠管的时间密度曲线和灌注参数均有明显变化。表现为:平均峰值降低,分别为（74.47±10.41）HU和（164.64±24.28）HU;平均峰值时间延长,分别为（57.34±4.45） s和（41.78±3.07）s;平均血流量降低,分别为（0.0021±0.0004）ml.s^-1ml^-1和（0.0056±0.0006）ml.s^-1ml^-1;平均血容量减低,分别为（0.0888±0.02 64）×100%和（0.1590±0.0339）×100%。统计学结果表明差异均有显著性（p<0.05）。结论CT灌注检查可反映缺血肠管的低灌注状态,可提供缺血的量化指标。更多还原

【Abstract】 Objective To discuss the CT perfusion methods of intestine and its diagnostic value of intestinal ischemia.Methods Mesenteric artery embolization were performed in 12 mongrel dogs.CT perfusion was performed pre- and postembolization.A SIEMENS Sensation 16 CT system was used.The time-attenuation curves of ROI were analyzed,the perfusion parameters were calculated.Results Comparing with the normal intestine,the perfusion parameters of ischemic intestine dropped significantly:the mean peak value decreased[（74.47±10.41）HU and（164.64±24.28）HU],the mean time to peak prolonged[（57.34±4.45）s and（41.78±3.07）s],the mean blood flow decreased[（0.0021±0.0004）ml.s^-1ml^-1and（0.0056±0.0006 ）ml.s^-1ml^-1],the mean blood volume decreased[（0.0888±0.0264）×100% and（0.1590±0.0339）×100%],which were statistically significant（p<0.05）. Conclusion The time-attenuation curve and perfusion parameters can reflect the lower perfusion states of ischemic intestine,CT perfusion may provide the quantitative parameters of ischemic intestine.更多还原