【摘要】 奥沙利铂(L-OHP)是消化道肿瘤化疗中应用最广的药物之一,以其为基础组成的FOLFOX4方案已成为进展期结、直肠癌公认的标准化疗方案。但患者对L-OHP的敏感性和不良反应有明显差异,其原因在于个体的药物遗传学特异性。文中从药物遗传学角度探讨如何预测L-OHP的化疗敏感性及不良反应,以指导胃肠癌临床个体化用药。更多还原

【Abstract】 Oxaliplatin is one of the most frequently used drugs in the treatment of gastrointestinal cancer,and the oxaliplatin-based chemotherapy(FOLFOX4) has become a standard regimen for advanced colorectal cancer.The effects and adverse events vary greatly from patient to patient because of individual pharmacogenetic specificity.This article investigates the prediction of the sensitivity and toxicity of oxaliplatin from the angle of pharmacogenetics to offer a guide to the individual treatment of gastrointestinal cancer.更多还原