【摘要】 采用液相色谱-串联质谱(LC-MS/MS)法测定大鼠血浆中亮菌甲素的浓度,研究亮菌甲素在大鼠体内药动学特征及其绝对生物利用度.结果表明,亮菌甲素灌胃给药(ig)1.44 mg和静脉注射给药(iv)0.9 mg后,在大鼠体内的主要药动学参数达峰浓度(cmax)分别为(58.33±23.41),(825.25±92.13)μg/L,半衰期(t1/2)分别为(1.55±0.43),(0.75±0.35)h,血药浓度-时间曲线下面积(AUC0~t)分别为(41.87±7.54),(140.64±19.73)h.(μg/L).经剂量校正后求得亮菌甲素在大鼠体内的绝对生物利用度(Fab)为18.61%.更多还原

【Abstract】 To investigate the pharmacokinetic characteristics of Armillarisin A and its absolute bioavailability in rats,1.44 mg and 0.9 mg of Armillarisin A were given via ig and iv to SD rats,respectively;the plasma concentration of Armillarisin A in rats was determined by LC-MS/MS.After ig administration of Armillarisin A,the main pharmacokinetic parameters cmax,t1/2,AUC0~t were(58.33±23.41) μg/L,(1.55±0.43) h,(41.87±7.54) h·(μg/L),respectively;After iv administration of Armillarisin A,the major pharmacokinetic parameters cmax,t1/2,AUC0~t were(825.25±92.13) μg/L,(0.75±0.35) h,(140.64±19.73) h·(μg/L), respectively.The absolute bioavailability was 18.61% after correction of dosage.更多还原