【摘要】 目的了解池州市贵池区农村社区人群实施乙肝疫苗接种后HBV感染状况和抗体水平以及人群HBV感染的血清流行病学变动趋势。方法采用分层整群随机抽样方法,对贵池区3个乡镇的450名农村居民进行问卷调查,并用ELISA法开展HBV感染标志的血清学检测。结果贵池区农村人群HBV流行率为38.68%,标化后人群HBV流行率为37.34%,HBsAg、抗-HBs、抗-HBc阳性率分别是9.67%、42.22%、14.15%;20岁以上人群HBV流行率为46.08%,HBsAg、抗-HBs、抗-HBc阳性率分别是10.84%、35.84%、15.66%;而20岁以下人群分别为11.96%、5.43%、65.22%、8.70%,各项指标在两年龄组中分布差异有统计学意义。HBV的各血清学指标在男女性别中分布差异无统计学意义。HBV流行率、抗-HBs阳性率和HBsAg阳性率在有、无HepB接种史的人群中分布差异有统计学意义,接种乙肝疫苗后HBsAg阳性率、抗-HBc及HBV流行率均降低。结论接种乙肝疫苗是控制农村地区人群HBV感染的有效措施。更多还原

【Abstract】 Objective To investigate the status of HBV infection and antibody levels and the seroepidemiological trend of the crowd after the implementation of hepatitis B vaccination in Chizhou City. Methods A cluster stratified sampling method was used to choose 450 rural population in Guichi City. 424 of them were investigated by filling a questionnaire, and their serological markers of HBV were detected with ELISA. Results The prevalence rates of HBV were 38.68% and the adjusted rates were 37.34%, while the positive rates of HBsAg, anti-HBs and anti-HBc were 9.67%, 42.22% and 14.15% respectively. Among the population older than 20, the prevalence rates of HBV were 46.08%, the positive rates of HBsAg, anti-HBs and anti-HBc were 10.84%, 35.84%, 15.66%. And in the population less than 20, they were 11.96%, 5.43%, 65.22%, 8.70% respectively. HBV infection markers between the two groups had significant differences (P<0.05). And there was no significant difference among the males and the females, too. The positive rates of HBsAg, anti-HBc and the prevalence rates of HBV in vaccines were significantly lower than those among the non-vaccines (P<0.05). Conclusions Widespread immunization with hepatitis B vaccine is the efficient measure to control and prevent Hepatitis B infection.更多还原