【摘要】 目的探讨纤溶酶原激活物抑制剂-1(PAI-1)-675 4G/5G及纤维蛋白原(Fg)β-148C/T基因多态性与脑梗死的关系。方法检测140例健康体检者(对照组)和220例脑梗死患者(CI组)PAI-1-675 4G/5G及Fgβ-148C/T基因多态性,并分析两组基因在正常人群及脑梗死患者中的频率分布特点。结果CI组Fgβ-148C/T位点T等位基因频率为0.33,对照组为0.225,两组比较差异具有统计学意义(P=0.0026)。CI组PAI-1-675 4G等位基因频率为0.48,对照组为0.56,两组比较差异具有统计学意义(P=0.037),以5G/5G基因型作为参考,4G/4G基因型发生CI的OR值为0.52(95%CI:0.282~0.958,P=0.027);携带CC和4G/4G基因型发生CI的OR值为0.48(95%CI:0.253~0.91,P=0.023)。结论本研究发现Fgβ-148T等位基因是CI发病的危险因素,4G/4G纯合子是CI的保护因素,CC基因型加强4G/4G基因型的CI保护作用。更多还原

【Abstract】 Objective To investigated the correlations of plasminogen activator inhibitor 1(PAI-1)-675 4G/5G gene polymorphism, beta fibrinogen-148C/T (Fgβ-148C/T) gene polymorphism and cerebral infarction (CI).Methods PAI-1 -675 4G/5G and Fgβ-148C/T genotypes of 220 cases and 140 health individual controls were identified, and their frequency distribution were analyzed.Results The frequencies of Fgβ-148C/T T allele in CI group and control group were 0.33 and 0.225, respectively (P=0.0 026), and the frequencies of PAI-1 -675 4G/5G 4G alleles in CI group and control group were 0.48 and 0.56, respectively (P=0.037). When considering 5G/5G homozygote as reference, the odds ratio (OR) was 0.52 (95% CI: 0.282～0.958,P=0.027) for 4G/4G homozygote. The risk factor of CI was 0.48 (95% CI: 0.253～0.91 P=0.023) for those with CC and 4G/4G genotypes.Conclusions The findings suggest that Fg β-148T allele are risk factors of CI. PAI-1 -675 4G/4G homozygote is a protective factor for CI. CC genotype strengthens the protective effect of 4G/4G genotype for CI.更多还原