【摘要】 目的观察阿奇霉素序贯治疗下呼吸道细菌感染的疗效及安全性。方法将我院2006年4月～2007年12月确诊为下呼吸道细菌感染的住院患者分为两组,A组56例,用阿奇霉素,注射液0.5g,iv,qd×3～5d后改用阿奇霉素胶囊0.5g,po,qd,总疗程7～14d的序贯治疗;B组54例,用左氧氟沙星序贯治疗。结果A、B组的总有效率分别为94.6%、96.3%,差异无统计学意义(P>0.05),细菌清除率分别为96.0%、85.4%,差异有统计学意义(P<0.05);不良反应发生率分别为17.9%、7.4%,差异有统计学意义(P<0.05),不良反应轻微,患者可耐受,不影响治疗。结论阿奇霉素序贯治疗下呼吸道细菌感染的疗效确切,安全性好。更多还原

【Abstract】 Objective To observe the curative effects and safety of azithromycin sequential therapy treating lower respiratory tract bacterial infection.Methods Categorize the inpatients who were diagnosed with lower respiratory tract bacterial infection from April 2006 to December 2007 into two groups.There were 56 cases in Group A.Intravenous injection of 0.5g azithromycin was administered once a day in Group A,azithromycin capsule was taken orally once a day after 3～5 days and the total treatment course of the sequential therapy was 7～14 days.There were 54 cases in Group B,with Levofloxacin sequential therapy.Results The total effective rate of Group A and Group B is 94.6% and 96.3% respectively,whose difference has no statistics significance (P>0.05),the bacterial clearance rate was 96.0% and 85.4% respectively,whose difference had statistics significance (P<0.05) and the incidence rate of the adverse reaction was 17.9% and 7.4% respectively,whose difference had statistics significance (P<0.05) The adverse reaction was mild and the patients can bear it,so it won’t influence the treatment.Conclusion Azithromycin sequential therapy has definite curative effects on the lower respiratory tract bacterial infection and the safety is good.更多还原