【摘要】 目的考察血脂异常对老年人脑梗死的影响。方法筛选100例脑梗死患者,年龄45～81岁,与100例健康受试者作对照,抽取受试者清晨空腹静脉血3mL,离心后将分离的血清置-25℃冰箱备用。采用双抗夹心ELISA法检测血清脂蛋白(a);氧化本科法检测血清总胆固醇(TC)和甘油三酯(TG);磷钨酸镁沉淀检测高密度脂蛋白(HDL-C);低密度脂蛋白(LDL-C)采用计算公式:LDL-C=TC-(TG/2.2+HDL-C);免疫比浊法检测载脂蛋白A、B(apoA、apoB)。结果脑梗死患者血清LPa、TC、TG、LDL-C、apoB水平显著高于对照组患者,血清HDL-C、apoA水平显著低于对照组,且患者组血清中各项脂质浓度异常发生率与对照组比较差异具有显著性,P<0.05。结论血脂异常与老年人脑梗死密不可分,调解血脂水平至正常对于预防和治疗老年人脑梗死具有重要义。更多还原

【Abstract】 Objective To investigate the effect of anomal-blood fat level on cerebral infarction in aged persons.Methods Screening 100 patients with cerebral infaction,aged 45～81.Contrasted to 100 healthvolunteer,collected 3mL venous blood from subjects in the early morning,separated the serum after centrifugalizatiom,and then put the serum in refrigerator,set up the temperature at- 25℃.Detected the lipoprotein(a)level by using double anti-sandwich ELISA,detected the total cholesterol and triglyceride content by oxidation enzyme methord,detected the high-density lipoproteins content by using magnesium phosphotungstic acid sedimentation, and calculated the low-density lipoprotein by the formula LDL-C=TC-(TG/2.2+HDL-C),detected apolipoprotein and apolipoprotein B by immunoturbidimetry.Results The level of lipoprotein(a);total cholesterol;triglyceride;low-density lipoprotein and apolipoprotein B in serum of cerebral infarction patients were higher than control group,and compared with control,the abnormality incidence rate of lipids concentration had significant difference,P<0.05.Conclusion There was close relationship between abuomal-blood fat level and cerebral infarction in aged patients,and regulation the level of blood fat has important significance on preventing and curing cerebral infarction in aged patients.更多还原