【摘要】 载脂蛋白E有ApoE2、ApoE3和ApoE4三种主要的异构体,有2ε、3ε和4ε三种常见的等位基因,其基因编码可形成ApoE2/2、ApoE3/3、ApoE4/4三种纯合子表型和ApoE3/2、ApoE4/3、ApoE2/4三种杂合子表型.不同种族间载脂蛋白E等位基因的频率和基因型频率都不同.载脂蛋白E基因多态性是个体间血脂水平差异的常见遗传因素,与个体间血脂代谢和血脂异常的发生存在一定的关联.此外,载脂蛋白E基因多态性可调节运动对血脂的影响,但其机制还有待于进一步的研究.更多还原

【Abstract】 Apolipoprotein E has three major Iso forms including ApoE2,ApoE3 and ApoE4,three major ApoE Iso forms are encolded by three alleles which are ε2,ε3 and ε4.Its six genotypes are ApoE2/2,ApoE3/3,ApoE4/4,ApoE3/2,ApoE4/3 and ApoE2/4.Gene frequency and genotype frequency are different in nationalities.Apolipoprotein E,gene polymorphism is significantly correlated with serum lipid level.Beyond,apolipoprotein E,gene polymorphism is related to the effect which exercise affects blood lipids.更多还原