【摘要】 目的探讨不同病程时期和不同剂量的AT1R拮抗剂对糖尿病视网膜病变(DR)的治疗作用。方法80只龄雄性Wistar大鼠,随机分为DR组(8只)和缬沙坦干预组,干预组按剂量分为大、中、小三组(各24只),每种剂量按给药时间分为第4周开始、第8周开始、第12周开始给药,三组分别给于缬沙坦40mg、10mg及4mg/kg体重灌胃治疗。给药后4周时各组对视网膜中AngⅡ和血管内皮细胞生长因子(VEGF)、组织转化因子β(TGF-β)、胰岛素样生长因子(IGF-1)及血小板衍生生长因子(PDGF)进行平均灰度和密度分析。结果缬沙坦治疗组大鼠同DR对照组比较,前者视网膜中VEGF,TGF-β,IGF-1及PDGF组显著降低,尤其以40mg/(kg.d)组更为明显。结论早期应用大剂量AT1R拮抗剂可一定程度改善DR,对视网膜起到保护作用。更多还原

【Abstract】 Objective To evaluate the effect of valsartan on several growth factors involving into diabetic retinopathy.Methods Eighty male Wistar rats were obtainedm and were randomly divided into diabetic retinopathy(DR,n=8) control group and treatment groups with valsartan 40,10 and 4 mg/(kg·d) by intragastric administration.The treatment were began after 4,8,12 weeks.The instrument for computer image-analysis was used to analyze the expression of vascular endothelial growth factor(VEGF),transgorming growth factor-β(TGF-β),insulin-like growth factor(IGF-1) and platelet derived growth factor(PDGF) in ganglion cell layer of retina.Results After treatment with 4 and 10 mg/kg valsartan,the expressions of VEGF,TGF-β,IGF-1 and PDGF were reduced than diabetic controls and further reduced with 40 mg/kg of valsartan.Conclusion During the early phase of DR,treatment of angiotensin 1 type receptor(AT-1R) antagonists could exert a potentially therapeutic effect upon the retina of DR.更多还原