<正>Inorganic lead (Pb) is one of the most common environmental pollutants.Much evidence indicates that Pb exposure could directly affect fish growth and development.In this study,we investigated the cytotoxic effects of Pb on cytoskeletal protein stability at both protein and mRNA level in crucian carp Carassius auratus.Pb(NO_3)_2 treatment in concentration of 100μmol/L resulted in decreased expression of bothα-andβ-tubulin but y-tubulin as assayed with SDS-PAGE,Western Blot, and ELISA.In vivo and in vitro ...
【英文摘要】
Inorganic lead (Pb) is one of the most common environmental pollutants.Much evidence indicates that Pb exposure could directly affect fish growth and development.In this study,we investigated the cytotoxic effects of Pb on cytoskeletal protein stability at both protein and mRNA level in crucian carp Carassius auratus.Pb(NO_3)_2 treatment in concentration of 100μmol/L resulted in decreased expression of bothα-andβ-tubulin but y-tubulin as assayed with SDS-PAGE,Western Blot, and ELISA.In vivo and in vitro ana...
【基金】
Supported by National Natural Science Foundation of China (No.30571414,No 30640015);
Changsha Municipal Project of Science and Technology (No.K051127-72).
【更新日期】
2009-02-20
【分类号】
X174
【正文快照】
1 INTRODUCTION RaPid growth of modern industry brings about Possible serious Pollution to the environment.Metal ions entering the environment from waste water may direetly or indireetly affect the living eonditions of fish or other aquatiean油als，whieh i
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