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HPLC测定甲睾酮喷雾剂中的甲睾酮

Determination of methyltestosterone in Methyltestosterone spray by HPLC

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【作者】 姚莉蓓冉兰刘梅妍

【Author】 YAO Li-bei,RAN Lan,LIU Mei-yan(West China School of Pharmacy,Sichuan University,Chengdu 610041,China)

【机构】 四川大学华西药学院四川大学华西药学院 四川成都610041四川成都610041

【摘要】 目的采用HPLC法测定甲睾酮喷雾剂的含量。方法色谱柱为Shimpack VP C18柱(150 mm×4.6 mm,5μm);流动相为甲醇-水(65:35);检测波长241 nm。结果甲睾酮0.052~4.160μg与峰面积的线性良好(r=0.9999);平均回收率为99.86%(RSD=0.98%,n=9)。结论所建方法简便、灵敏、准确,可用于甲睾酮喷雾剂的含量测定。

【Abstract】 OBJECTIVE To establish a method to determine methyltestosterone in Methyltestosterone spray by HPLC.METHODSShimpack VP C18(150 mm×4.6 mm,5 μm) column was used with the mobile phase consisted of methanol-water(65:35).The ultraviolet detector was set at 241 nm.RESULTS A good linearity was obtained in the range of 0.052-4.160 μg(r=0.9999).The average recovery was 99.86%(n=9) with RSD of 0.98%.CONCLUSIONThe method is simple,sensitive and applicable for the determination of methyltestosterone in Methyltestosterone spray.

  • 【文献出处】 华西药学杂志 ,West China Journal of Pharmaceutical Sciences , 编辑部邮箱 ,2008年02期
  • 【分类号】R927
  • 【被引频次】5
  • 【下载频次】86
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