【摘要】 研究了在碳酸氢钠-二甲亚砜催化体系中,酮经Trofimov反应一锅法制备吡咯衍生物。以苯乙酮为原料,生成3-苯基吡咯和1-乙烯基-3-苯基吡咯,反应温度及催化剂的用量对产品收率的影响。其最佳反应条件为:常压,100°C,前者收率为66.2%;后者收率为33.4%。催化剂用量均以NaHCO3/mg:DMSO/mL=420∶10为宜。产物IR及1H NMR均与文献值一致。更多还原

【Abstract】 A one-pot synthesis of pyrroles form ketone via the Trofimov reaction catalyzed by NaHCO₃-DMSO was introduced.Acetophenone was used as starting material to give out 3-phenylpyrrole and 1-vinyl-3-phenylpyrrole.The influence of temperature and catalyst dosage was studied.The optimum reaction conditions were: normal pressure and（100°C）.The yield of the former was 66.2%;while the latter was（33.4%）.The optimum amount of catalyst for both reactions were the same,i.e.NaHCO₃/mg: DMSO/mL=420∶10.Results of IR and（）¹H NMR of the products agreed with those in the literature.更多还原