【摘要】 硫酸类肝素是一种结构十分复杂,承担着多种独特生物功能的糖胺聚糖。本文解析了硫酸类肝素的分子结构特征以及分子结构与生物功能之间的关系,综述了对硫酸类肝素结构修饰与功能模拟、生物和化学合成等方面的研究进展,对该领域研究体系和研究方法进行了评述和展望。更多还原

【Abstract】 Heparan sulfate is a typical kind of glycosaminoglycan(GAG),having complex structures and charged with many particular biological activities.This paper elucidates the structures of heparan sulfate and the structure-function relationships,reviews the chief work of structural modification,simulation, as well as biosynthesis and chemical synthesis.更多还原