【摘要】 本文综述了天然多糖聚电解质海藻酸钠和壳聚糖的结构与化学性能(包括凝胶性能、生物相容性、生物可降解性及温和反应性);微胶囊制备技术及其强度性能和膜渗透性评价方法;微胶囊作为细胞载体在体内分泌治疗性物质(如:胰岛素、多巴胺)或分解代谢毒性物质(如:尿素),作为三维药物筛选系统、干细胞增殖分化研究工具,以及药物释放载体等生物医学领域的研究进展;最后讨论了天然多糖微胶囊在研究与应用中需要解决的问题。更多还原

【Abstract】 This review highlights the progress in the structure and chemical properties of natural polysaccharides(alginate and chitosan) including gel formation,biocompatibility,biodegradability and mild reaction ability;preparation technologies of microcapsules(polyelectrolyte complexation/polyelectrolyte layer-by-layer self assembly),and the evaluation methods on microcapsule’s mechanical and permeable properties;microcapsules entrapping cells secreting therapeutics(such as insulin and dopamine) or decomposing toxic metabolites(such as urea) in vivo,microcapsules serving as three-dimensional drug screening systems and microenvironment for the proliferation and differentiation of stem cells,microcapsules serving as the drug carriers for controlled release.Finally,the challenge and problem for the development of microcapsules are discussed.更多还原