【摘要】 目的荆芥不同粒径粉体的解热镇痛作用的比较研究。方法通过鲜啤酒酵母致家兔体温升高实验比较其解热作用;采用热板法、扭体法实验对比其镇痛作用。结果与对照组比较,荆芥超微粉能明显抑制鲜啤酒酵母致家兔体温升高,差异有统计学意义(P<0.05～0.01);明显提高小鼠的痛阈值、减少扭体次数,差异有统计学意义(P<0.05)。与普通粉高剂量组比较,荆芥超微粉低剂量解热、镇痛作用差异无统计学意义(P>0.05),荆芥超微粉中剂量解热作用差异有统计学意义(P<0.05),等剂量荆芥超微粉解热、镇痛作用差异均有统计学意义(P<0.05)。结论荆芥超微粉体的解热、镇痛作用均优于其他两种粒体。提示荆芥超微粉临床使用剂量可减少至普通粉剂量的1/4～1/2。更多还原

【Abstract】 Objective To compare the effects of powders with different diameters of schizonepeta on anti-pyretic and analgesic effects.Methods The anti-pyretic effect was com-pared with fever induced by fresh beery in rabbit,and the analgesic effect by the hot-plate procedure and torsion body in mice.Results Compared with the model group,the micropowder of schizonepeta obviously lowered rabbit’s temperature(P<0.05～0.01) and obviously improved value of pain threshold,reduced the times of body sprain(P<0.05).Compared with the high dose of common powder,there was not significant difference in low dose of micropowder on anti-pyretic and analgesic effects(P>0.05),and the difference in the mid dose of micropowder was significant on anti-pyretic effect(P<0.05);Compared with same dose of common powder,there was significant difference on anti-pyretic and analgesic effect in micropowder(P<0.05).Conclu-sion The effects of schizonepeta micropowder are better than that of other two powders,which suggest that the dose of the micropowder can use 1/4～1/2 of common powder in clinic.更多还原