【摘要】 目的:观察肝硬化患者血清脂联素水平,探讨其与胰岛素、Child-Pugh分级和肝功能等指标间的关系。方法:53例肝硬化患者按照Child-Pugh分级,采用ELISA法测定血清脂联素水平,计算体质指数,并测定空腹血糖、血脂、肝功能和血清胰岛素,以20名体检健康者作为对照组进行比较。结果:肝硬化患者血清脂联素水平明显高于正常对照组(P<0.05),且Child C级>B级>A级(P<0.05)。脂联素水平与胰岛素和TBA呈正相关,与肝硬化病因、AST、ALB、TBIL等因素无关。腹水脂联素水平明显低于血清脂联素(P<0.01)。结论:血清脂联素水平在肝硬化时明显升高,且与病情具有一定的相关性,可作为临床评估肝硬化的参考指标。更多还原

【Abstract】 Objective To investigate the levels of adiponectin and the relationship with insulin,Child-Pugh,and parameters of liver function in patients with liver cirrhosis.Methods Serum adiponectin levels were measured in 20 healthy controls and 53 patients with liver cirrhosis,including different Child-Pugh classification grade by using ELISA.Meanwhile,some clinical parameters were determined,such as insulin,fasting blood glucose,liver functions,body mass index and so on.In addition,adiponectin level in ascites was also measured.Results The serum adiponectin level was significantly higher in patients with liver cirrhosis than that in control group(P<0.05),and the ranking of adiponectin levels in patients with different Child-Pugh classification grade was: C > B > A(P<0.05);the adiponectin positively correlated with the insulin and TBA(P<0.05),however,it was not associated to the aetiology of liver cirrhosis,AST,ALB,TBIL respectively.The adiponectin level in ascites was significantly lower than that in peripheral blood.Conclusion The value of serum adiponectin evidently increases in patients with liver cirrhosis and is positively correlated with Child’s stage,which could be used to evaluate the degree of liver cirrhosis.更多还原