【摘要】 【目的】通过podoplanin对鼻咽癌中淋巴管进行标记,探讨血管内皮细胞生长因子-C(VEGF-C)与鼻咽癌淋巴结转移和淋巴管生成的关系。【方法】采用VEGF-C、podoplanin抗体对60例鼻咽癌和10例无肿瘤、形态基本正常的鼻咽部黏膜组织进行免疫组化染色,并结合临床病理参数及预后进行分析。【结果】鼻咽癌中VEGF-C的表达明显高于对照组(P=0.000);VEGF-C和肿瘤淋巴结转移分期明显相关(r=0.382,P=0.003),同时和肿瘤的临床分期也密切相关(r=0.305,P=0.018)。肿瘤中淋巴管的数目和肿瘤的淋巴结转移分期明显相关(r=0.406,P=0.003),并且淋巴管的数目和肿瘤中VEGF-C的表达明显相关(r=0.471,P=0.001)。【结论】VEGF-C的高表达引起肿瘤淋巴管生成增多,促进鼻咽癌更广泛的淋巴结转移。更多还原

【Abstract】 [Objective] To investigate the relationship between the expression of VEGF-C and lymph node metastasis and lymphagiogenesis in nasopharyngeal carcinoma by marking the lymphatic with podoplanin.[Methods] The expression of VEGF-C and podoplanin in 60 patients with nasopharyngeal carcinoma and 10 normal patterns of tissues without tumor was detected by immunohistochemical staining,and analyzed in combination with clinical and pathological prognostic parameter.[Results] VEGF-C expression in nasopharyngeal carcinoma was significantly higher than that in control group(P=0.000),and significantly correlated with tumor lymph node metastasis(r=0.382,P=0.003) and closely correlated with the clinical stage(r=0.305,P=0.018).The number of lympgatic vessel was significantly correlated with tumor lymph node metastasis(r=0.406,P=0.003) and was closely correlated with the expression of VEGF-C in tumor(r=0.471,P=0.001).[Conclusion]The high expression of VEGF-C may lead to lymphangiogenesis of tumor,and may lead to more extensive metastasis in nasopharyngeal carcinoma.更多还原