【摘要】 【目的】观察抗抑郁药物帕罗西汀联合心理干预对脑卒中后抑郁的疗效。【方法】96例卒中后抑郁症患者随机分为治疗组和对照组各48例,两组均给予帕罗西汀20mg/d晨服;治疗组同时采用心理治疗。治疗前后8周末分别用汉密尔顿抑郁量表(HAMD)、中国卒中量表(CSS)评定其疗效。【结果】治疗8周后,两组的HAMD、CSS评分均明显低于治疗前,且治疗组均优于对照组,差异均有显著性(P<0.01)。治疗组抑郁总有效率、神经功能恢复总有效率均为93.7%,明显高于对照组的77.1%和79.2%(P<0.01)。【结论】帕罗西汀联合心理干预有良好的抗抑郁及促进神经功能恢复的作用,疗效优于单纯药物治疗。更多还原

【Abstract】 [Objective] To study the effects of Paroxetine combined with psychotherapy in treating post-stroke depression.[Methods] In this study,a total of 96 patients with post-stroke depression were divided into 2 groups randomly.Among all patients,48 patients were treated with Paroxetine(Control group) and other 48 patients were treated with Paroxetine combined with psychotherapy(Treatment group) for 8 weeks.HAMD and CSS were used to evaluate the symptoms improvement and side effects.[Results] After 8 weeks treatment,HAMD and CSS scores obviously decreased in two groups,but these scores in the treatment group were lower than those in the control group.There were significant differences in two groups(P<0.01).The total rate of effectual remedy for anti-depression and recovery neurological function were obviously higher in treatment group(93.7%,93.7%) than those in control group(77.15%,79.2%).[Conclusion] Paroxctine combined with psychotherapy can obviously improve anti-depression and recovery degree of neurological function.更多还原