【摘要】 【目的】探讨西酞普兰治疗抑郁症的有效性和安全性。【方法】63例抑郁症患者随机分为两组,分别采用西酞普兰或氟西丁治疗后评定其疗效及安全性。【结果】经6周治疗,西酞普兰组与氟西丁组的有效率分别为85.24%和82.35%,治愈率分别为64.71%和56.18%,两组间有效率和治愈率差异无显著性,西酞普兰组与氟西丁组的HAMD量表总分分别由治疗前的(31.42±8.54)分和(32.47±6.69)分下降至治疗后的(9.65±7.24)分和(9.79±5.62)分,两组治疗后各周与治疗前比较差异有显著性,两组间差异无显著性。西酞普兰组的主要不良反应是恶心、头痛、口干和失眠;氟西丁组的主要不良反应为呕吐/恶心、体重增加、头痛。【结论】西酞普兰是一种安全有效的新型抗抑郁药物,具有较好的抗抑郁作用。更多还原

【Abstract】 [Objective] To explore the efficiency and safety of Citalopram in the treatment of depressive patients. [Methods] Sixty three patients with depression were randomly divided into two groups, which received orally Citalopram 20mg or Fluoxetine 20mg once a day, respectively. HAMD was used to evaluate the treatment effects. The safety was monitored by TESS, physical and laboratory examinations. [Results] After six weeks of treatment, the effective rates were 85.24% and 82.35%,and the curative rates were 64.71% and 56.18%, respectively, in group Citalopram and group Fluoxetine. There were no significant differences in the effective and curative rate between two groups. And the HAMD scores were 9.65±7.24 and 9.79±5.62 decreased from 31.42±8.54 and 32.47±6.69, respectively, in group Citalopram and group Fluoxetine. There were also no significant differences between two groups. The main side effects of Citalopram were vomiting, headache, dry mouth and insomnia. The main side effects of Fluoxetine were vomiting, weight gain and headaches. [Conclusion]Citalopram is a safe and effective new drug for treatment of depression.更多还原