【摘要】 【目的】探讨急性冠脉综合征并发糖代谢异常的发病特点及预后的影响。【方法】分析急性冠脉综合征患者194例,分为合并糖尿病组(T2DM)39例,并合糖调节异常组(IGT/IFG)51例,合并糖代谢正常组(NGT)61例,合并应激性高血糖组(SHG)43例。所有患者均测定空腹血糖(FPG)、餐后两小时血糖(2hPG)、出院前3~4d行口服糖耐量试验(OGTT),根据OGTT结果分为4组,比较各项临床指标。【结果】在急性冠脉综合征患者中合并糖代谢异常患者约占总数的2/3,糖代谢紊乱组(T2DM、IGT/IFG、SHG)的血糖数据显著高于NGT组,其血脂紊乱的特点以高甘油三酯、低HDL-C为主要特点,而NGT组则以高总胆固醇、高LDL-C为特点。T2DM及IGT/IFG组冠脉造影示多支病变,弥漫性血管病变多见。【结论】急性冠脉综合征并糖代谢异常者发病率明显升高,主要心血管事件发生率明显升高。更多还原

【Abstract】 【Objective】To research the clinical features of acute coronary syndrome(ACS) complicated with glycometabolism disorder and the impact of abnormal glycometabolism on the prognosis of patients with ACS.【Methods】There were 194 patients with ACS in the study.According to WHO criterion in 1999,these cases were divided into four groups,diabetes group(T2DM,n=39),IGT/IFG group(n=51),normal glycometabolism group(NGT,n=61) and stress hyperglycemia group(SHG,n=43).All of subject investigated in the study were evaluated by a series of clinical examination,such as blood lipid and coronary angiography,etc.【Results】The patients with glycometabolism disorder(T2DM,IGT/IFG and SHG groups) were two thirds of the total of patients in the study,and the chief feature of their blood lipid disorder was high TG and low HDL-C,but that of dyslipidemia in normal glycometabolism group was high TC and LDL-C.The manifestations of coronary arteriography in both T2DM and IGT/IFG were multi-branch vasculopathy and diffuse lesion.【Conclusion】The incidence of glycometabolism disorder(including stress hyperglycemia)in patients with ACS is markedly rising,in which major cardiovascular events are also noticeably increasing.更多还原