【摘要】 目的:评价胸腺肽-α1对胃肠道肿瘤患者围手术期细胞免疫功能的影响。方法:40例胃肠道肿瘤患者被随机分成胸腺肽组和对照组,每组各20例。胸腺肽组于术前1 d、术后3 d,分别皮下注射胸腺肽-α1 1.6 mg,对照组不做此处理。全部病例于术前1 d、术后2,7 d分别抽取外周静脉血,检测T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞CD56+的数目。结果:术后第2天,两组CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞CD56+与术前相比均显著下降(P<0.05),但下降的幅度不同,胸腺肽组下降的幅度大,组间比较有显著性差异(P<0.05);术后第7天,两组各项指标恢复至术前水平,组间比较无显著性差异(P>0.05);两组CD8+变化不明显。结论:胸腺肽-α1可以改善围手术期机体的免疫功能抑制状态,促进患者免疫功能的恢复。更多还原

【Abstract】 Objective:To investigate the effects of thymosin-α1 on cellular immune of patients with tumors of stomach and intestine in perioperative period.Methods:Forty patients with tumors of stomach and intestine were divided randomly into trial group(n=20) and control group(n=20).Patients in trial group were injected subcutaneously thymosinα1 1.6 mg 1 day before operation and 3 day after operation;patients in control group didn’t use relative agent.Peripheral venous blood samples were taken the first day before operation,the second day and the seventh day after operation for the determination of subgroups of T cell and NK cell:CD3+,CD4+,CD8+,CD4+/CD8+ and CD56+.Results:Compared with the levels before the operation,CD3+,CD4+,CD8+,CD4+/CD8+ and CD56+ decreased markedly in both groups (P<0.05)on the second day after the operation,especially in trial group;of which,there was significant difference between the two groups(P<0.05).On the seventh after the operation day,the levels of CD3+,CD4+,CD8+,CD4+/CD8+ and CD56+ recovered to preoperational levels in both groups,compared with the two groups,there was no significant difference(P>0.05).There was no significant change at CD8+ level all the time.Conclusion:Thymosin-α1can alleviate the immune inhibited condition of patients with tumors of stomach and intestine in perioperative period,and promote recovery of the immune after operation.更多还原