【摘要】 目的:探讨转化生长因子β(TGF-β)在非小细胞肺癌中的表达及意义。方法:应用免疫组化法检测了41例非小细胞肺癌标本中TGF-β的表达。结果:TGF-β阳性表达率为65.85%。NSCLC肿瘤组织中TGF-β表达与癌旁组织及正常肺组织中比较有显著意义(P>0.01)。TGF-β的阳性表达与病变分期有关,在NSCLC的Ⅰ期与Ⅱ期及Ⅰ期与Ⅲ期之间有显著差异(P<0.01),TGF-β表达与和淋巴结转移有关(P<0.05),但与组织分型无关。结论:TGF-β在NSCLC中高表达,其表达与肺癌恶性生物学行为关系明显,是评估患者预后的指标之一。更多还原

【Abstract】 Objective:To study the significance of transforming growth factor beta(TGF-β)in non-small cell lung carcinoma(NSCLC).Methods:The expression s of TGF-βis detected in 41 cases of NSCLC with immunohistochemistry.Results:The total positive rate was 65.85%.Positive TGF-βexpression in carcinomatous specimen was stronger than that in para-carcinomatous and nor- real lung tissue specimen(P<0.01).NSCLC was detected and it was related with NSCLC pro- gression.Significant difference of the expression of TGF-βwas found between stageⅠandⅡ(P<0.01),and between stageⅠandⅢ(P<0.01),and the positive expression of TGF-βwas significantly higher in the patients with lymph node metastasis than those without lymph node me- tastasis(P<0.05).No significant association was found between the TGF-βexpression and the characteristics of the histological types in NSCLC.Conclusion:Positive TGF-βexpression in carci- nomatous specimen was detected.The expression s of TGF-βis correlated with malignant biological behavior of NSCLC,and have important value on predicting the prognosis of patient with NSCLC.更多还原