【摘要】 目的:探讨位于或邻近中央区良恶性脑肿瘤手运动及感觉功能区血氧水平依赖对比成像的核磁共振功能成像(blood oxygenation level dependent functional magnetic resonance imaging,BOLD-fMRI)的形态、体积和最大信号强度改变特征。方法:收集13例正常志愿者、31例经病理证实的位于或邻近中央区的脑肿瘤患者(良性肿瘤13例,恶性肿瘤18例)。对所有患者及正常志愿者行双侧手运动及感觉功能BOLD-fMRI检查。在离线工作站用SPM软件对BOLD-fMRI原始数据进行处理得出功能区激活图、体积及信号强度,激活图与T1解剖图的叠加像。对功能区体积及信号强度数据进行统计学分析。结果:正常功能区激活图体积存在半球优势;良、恶性脑肿瘤及与正常志愿者之间功能区激活信号像素数及最大信号强度存在差异性(P<0.05);脑肿瘤导致功能区形态、解剖位置、体积及最大信号强度的改变。结论:BOLD-fMRI能直观地显示运动及感觉功能区的基本形态和解剖位置,经过后处理可计算出其体积大小及最大信号强度,是对脑肿瘤患者进行手术前风险评估的有效手段。更多还原

【Abstract】 Objective To explore the geomorphological performance,the characteristics of volume,and the largest signal intension of blood oxygenation level dependent functional magnetic resonance imaging(BOLD-fMRI) in brain tumors located in or closed to the central area.Methods We recruited 13 normal volunteers and 31(13 benign tumors and 18 malignant tumors) patients with brain tumor located in or closed to the central area,to examine both side hand motor and tactile function by BOLD-fMRI and obtained the activation map and its superposition image with T1 imaging,the volume,and the largest signal intension of the functional area by SPM software which manipulated the raw data in the off-line work station.The volume and the largest signal intension data of the functional area were ststistically analyzed by SPSS 13.0.Results The volume and the largest signal intension of the activation map in the normal functional area had hemisphere advantage.There was difference in the activated signal pixel number and the largest signal intension of the functional area between the benign brain tumors,malignant brain tumors,and the normal volunteers(P<0.05).The shape,anatomic location,the volume,and the largest signal intension of the functional area were changed in the patients with brain tumors.Conclusion BOLD-fMRI is a valid method to assess the pre-surgical risk of patients with brain tumors,which can get the volume,the largest signal intension,the basic shape,and the anatomic location of the functional area.更多还原