【摘要】 研究了碱性功能化离子液体氢氧化1-丁基-3-甲基咪唑([bmim]OH)催化环己酮、芳香醛、芳香胺的三组分Mannich反应。原料比例为n(环己酮):n(芳香醛):n(芳香胺):n([bmim]OH)=1:1:1:0.1,以乙醇为溶剂,室温条件下反应10h,生成相应的β-氨基酮,产率达75%～91%。探讨了溶剂种类和醛、胺的结构对Mannich反应的影响。离子液体可以重复使用5次,其催化活性并未明显降低。更多还原

【Abstract】 Three-component Mannich reaction of cyclohexanone,aromatic aldehydes and aromatic amines catalyzed by a basic functionalized ionic liquid,1-butyl-3-methylimidazolium hydroxide([bmim]OH),was investigated.Under the optimum reaction conditions as n(cyclohexanone):n(aromatic aldehydes):n(aromatic amines):n([bmim]OH)=1:1:1:0.1,and at room temperature for 10 h with CH3CH2OH as a solvent,the yields of β-amino ketones was obtained with 75%-91%.The factors influencing the Mannich reaction were discussed including solvents,the structure of aldehydes and amines.The ionic liquid,which is environment friendly,was recycled at least 5 times without significant loss of activity.更多还原