【摘要】 目的观察全身化疗联合腹腔化疗对晚期卵巢癌的疗效及毒副反应。方法24例卵巢癌,用紫杉醇135 mg/m2,卡铂400mg/m2静滴,每4周重复1次,共化疗2个周期,顺铂60 mg,地塞米松10 mg腹腔化疗,每2周1次,进行2~3个周期,中位疾病进展时间(MTTP)9个月(5~12个月),无复发生存期5个月,观察每次化疗毒副反应及疗效。结果24例中CR 12例、PR 7例,RR79.2%,毒副反应为剂量限制性骨髓抑制、消化道反应。结论全身化疗联合腹腔化疗对晚期卵巢癌有较好疗效。更多还原

【Abstract】 Objective To evaluate the results and toxicity of chemotherapy combined with intraperitoneal chemotherapy in advanced ovarian carcinoma.Methods 24 cases with advanced ovarian carcinoma were treated with paclitaxel 135 mg/m2 and carboplatin 400 mg/m2 intravenous chemotherapy,cisplatin 60 mg and dexamethasone 10 mg intraperitoneal chemotherapy.Results 24 cases were eligible for evaluation,the overall response rate was 79.2%(12 complete response and 7 partial response),median TTP were 9 months(5-12 months).The dose-limited toxicity was mild and mainly expressed as arrest of bone marrow,nausea,vomiting.Conclusion A higher response rate is attainable in patients with advanced ovarian carcinoma by chemotherapy and intraperitoneal chemotherapy.更多还原