【摘要】 目的观察CPT-11联合草酸铂、5-Fu作为二、三线方案治疗晚期大肠癌的近期疗效及毒副反应。方法12例晚期大肠癌,均于2006年10月至2008年3月在江苏省肿瘤医院化疗科接受二、三线化疗。具体方案为草酸铂85 mg/m2,iv gtt,d1,8,15;5-Fu 600mg/m2,iv gtt d1-5;CPT-11 60 mg/m2,iv gtt,d2,9,16。28 d为1周期,2个周期后评估疗效及毒副反应。结果可评价疗效12例,其中PR 3例,SD 6例,PD 3例,有效率25%,临床获益率75%。主要毒副反应为恶心、呕吐、迟发性腹泻、肝脏损害、神经毒性和骨髓抑制等。结论CPT-11联合草酸铂、5-Fu方案二、三线治疗晚期大肠癌有较好的疗效,且毒副反应可以耐受。更多还原

【Abstract】 Objective To investigate the efficacy and safety of CPT-11 combined with oxaliplatin and 5-Fu as second or third line treatment for advanced colorectal cancer patients.Methods From October 2006 to March 2008,12 patients of Jiangsu Tumor Hospital & Research Institute with pathologically confirmed advanced colorectal cancer entered into this study.Chemotherapy regimen contained oxaliplatin 85 mg/m2,iv gtt,d1,8,15;5-Fu 600 mg/m2,iv gtt d1-5;CPT-11 60 mg/m2,iv gtt,d2,9,16,every 4 weeks as a cycle.Assessment on efficacy and toxicity was conducted after two cycles.Results After two cycles of treatment,3 patients achieved partial remission,6 with stable and 3 with progressed disease.Thus, response rate was 25%(3/12),clinical benefit rate was 75%(9/12).Major toxicities included nausea,vomiting,delayed diarrhea,liver damage,neurological toxicity and myelosuppression,etc.Conclusion The combination of CPT-11,oxaliplatin and 5-Fu as a second or third line chemotherapy for advanced colorectal cancer has rational efficacy and is well tolerated.更多还原