【摘要】 考察复方滴丸制剂中黄芩苷体内药动学的特征,以获得药动学参数为临床应用提供参考依据.给大鼠灌服肝复康滴丸后,于不同时间采取血样,用高效液相色谱仪测定血药浓度,通过DAS2.0药动学软件自动拟合数据获得药动学参数.大鼠灌胃给予肝复康滴丸后黄芩苷药动学行为符合二室模型,按黄芩苷3.6 g/kg灌胃后主要药动学参数Ka、tm ax、Cm ax、AUC、t1/2(Ka)、K21、K12、K10分别为22.744(1/h)、0.5 h、20.43μg/mL、124.296(μg/mL)h、0.03 h、0.068(1/h)、2.343(1/h)、5.891(1/h).药代动力学实验表明,肝复康滴丸中黄芩苷在体内的分布较快而代谢排除的速度较慢.更多还原

【Abstract】 To investigate the pharmacokinetics property of baicalin in Ganfukang dropping pill in vivo and to take the pharmacokinetics parameters so that providing reference data for clinic.After orally administrated to rats,the blood samples are taken during the different times and the baicalin concentration in blood samples are determined with HPLC instrument.The pharmacokinetics parameters are taken by auto-fitting data with DAS2.0 pharmacokinetics software.The baicalin in Ganfukang dropping pill shows to be 2-compartment model,and the main pharmacokinetics parameters such as Ka,tmax,Cmax,AUC,t1/2(Ka),K21,K12,K10 are 2.744(1/h),0.5 h,20.43μg/mL,124.296(μg/mL)h,0.03 h,0.068(1/h),2.343(1/h),5.891(1/h) respectively.The absorption and distribution of baicalin in Ganfukang dropping pill are faster,but the elimination is slower.更多还原