【摘要】 以阿霉素为模型药物,采用薄膜分散-pH梯度法制备羧甲基壳聚糖修饰的纳米脂质体,并研究了该纳米脂质体的包封率、形态、粒径、稳定性和pH敏感性。结果表明:羧甲基壳聚糖修饰后阿霉素脂质体的ζ电位、酸性条件下药物渗漏速率、渗漏百分率比未修饰的阿霉素脂质体均有明显提高。所制pH敏感阿霉素纳米脂质体包封率达87%左右,体积粒径为(74.7±11.5)nm;4℃冷藏保存3个月稳定性良好。更多还原

【Abstract】 The film-pH gradient method was used to prepare carboxymethyl chitosan(CMCT) modified pH-sensitive nanoliposomes by using doxorubicin(DXR) as a model drug.The encapsulation effi-(ciency,) morphology,particle size distribution,stability and pH-sensitivity of the pH-sensitive nanoliposomes were investigated.The results show that the ζ potential,the rate and percent of drug release in(acidic) condition of the nanoliposomes all increased significantly after modification and better pH-sensitivity can be gained.The encapsulation efficiency of the pH-sensitive DXR nanoliposomes can reach about 87%.They are spherical with particle size distribution of(74.7±11.5) nm,which remain quite stable conserved in refrigerator at 4(°C) for 3 months.更多还原