【摘要】 介绍盐酸头孢吡肟的一种合成新方法。此方法以7-氨基-3[(1-甲基-1-吡咯烷基)甲基]头孢-3 -烯-4羧酸盐酸盐和2-甲氧亚氨基-2-(2-氨基-4-噻唑基)-(z)-乙酸二乙基磷酰活性酯为起始原料,具有收率高,杂质低,成本低等优点,并利用核磁共振和质谱对产物进行了表征。更多还原

【Abstract】 One new synthetic method of cefepime dihydrochloride using 7-amino-3-[(1-methyl-1- pyrrolidino)methy]ceph-3-em-4-carboxylate hydrochloric salt and diethyl phosphoryl (Z)-2-(2-aminothiazol-4 -yl)-2-(methoxyimino) acetate as the startng materials was developed with high yield,lowi impurities,and low costetc. LC-MS and 13C-NMR were used to characterize the structure of the compound.更多还原