【摘要】 利用正硅酸乙酯在W/O乳液中的原位水解聚合,成功制备了包埋井冈霉素的二氧化硅载药空心微球.对所得产品进行了SEM,XRD,FT-IR和粒径分布等分析,结果表明,载药空心微球粒径分布窄,范围在7.5~15μm,球状形貌良好,具有空心结构,呈无定型态.热重分析表明载药空心微球的药物负载量约为31.9%(ω),缓释溶出实验显示载药空心微球药物释放持续时间约240min,最终释放量达总载药量的90%以上.更多还原

【Abstract】 Validamycin-loaded silica hollow microspheres were prepared by in situ hydrolysis of tetraethyl orthosilicate (TEOS) in Water-Oil (W/O) emulsions. The microspheres were characterized by SEM, XRD, FT-IR and particle size distribution. The results indicated that the drug-loaded microspheres had an amorphous hollow spherical structure with the diameters of 7.5~15 μm. The amount of validamycin entrapped in the microspheres was about 31.9%(ω). Sustained-releasing studies showed that the release time was about 240 min and more than 90% of the loaded drug in the microspheres was delivered, indicating good sustained release behavior of the drug-loaded microspheres.更多还原