【摘要】 目的:了解纳洛酮治疗慢性Ⅱ型呼吸衰竭的疗效。方法:将46例慢性Ⅱ型呼吸衰竭患者随机分成两组,在常规治疗基础上观察组每日一次用纳洛酮1.6mg加入5%葡萄糖盐水250ml中静滴;对照组用可拉明1.875g加入5%葡萄糖盐水250ml中缓慢静滴,疗程均为5d;观察临床症状、体征、肺功能、血气分析及副作用。结果:治疗后观察组在临床症状、体征、肺功能、血气分析等各项观察指标的改善上明显优于对照组,差异具有统计学意义(P<0.05);观察组总有效率为91.30%,对照组为65.22%,差异具有有统计学意义(P<0.05);且纳洛酮未见明显副作用。结论:纳洛酮治疗慢性Ⅱ型呼吸衰竭患者是一种安全有效的方法,值得临床推广应用。更多还原

【Abstract】 Objective: To estimate the clinical effect of naloxone in the treatment of chronic type Ⅱrespiratory failure.Method: 46 cases of chronic type Ⅱrespiratory failure were randomly divided into two groups,namely the observation group and the controlled group.On the base of routine treatment,1.6 mg of Naloxone and 250ml of 5% GS was used once per day in the observation group.The course of treatment was 5 days.The clinical symptom,sign,lung function,blood gas analysis and side effect were observed in the article.Result: There was significantly difference between two groups in lung function, blood gas analysis(P<0.05).The cure rate of observation group was significantly higher than that of control group(91.30% vs 65.22%,P<0.05),and naloxone had few side effects.Conclusion: Naloxone is a safe and effective drug in treating chronic type Ⅱ respiratory failure,which is worth utilizing widely in clinic.更多还原