节点文献
罗沙替丁乙酸酯衍生物的合成
Synthesis of Roxatidine Derivatives
【摘要】 N-{3-[3-(1-哌啶甲基)苯氧]丙基}氯乙酰胺与伯胺反应,合成了3个罗沙替丁乙酸酯衍生物,再与草酸反应成盐得对应的草酸盐,其结构经1H NMR和MS表征。
【Abstract】 Three roxatidine derivatives(3) were designed and synthesized by the reaction of N-{3-[3-(1-methylpiperidine)phenoxy]propyl}chloroacetamide with primary amine,and then with oxalic acid to obtain thier salts.The structures were confirmed by 1H NMR and MS.
【关键词】 罗沙替丁乙酸酯;
衍生物;
伯胺;
H2-受体拮抗剂;
药物合成;
【Key words】 roxatidine; derivative; synthesis; antiulcer agent;
【Key words】 roxatidine; derivative; synthesis; antiulcer agent;
- 【文献出处】 合成化学 ,Chinese Journal of Synthetic Chemistry , 编辑部邮箱 ,2008年06期
- 【分类号】R914
- 【下载频次】195