节点文献

罗沙替丁衍生物的合成

Synthesis of Roxatidine Derivatives

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 ZHANG Hui1,ZHANG Qian-yun2,LIN Li1,CHENG Mao-sheng3(1.Department of Chemistry,Shenyang Medical College,Shenyang 110034,China;2.College of Commonality Health,China Medical University,Shenyang 110001,China;3.School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China)

【机构】沈阳医学院化学教研室；中国医科大学公共卫生学院；沈阳药科大学制药工程学院辽宁沈阳110034；辽宁沈阳110001；辽宁沈阳110034；辽宁沈阳110016；

【摘要】以间羟基苯甲醛为原料,经3步反应合成了N-{3-[3-(1-甲基哌啶)苯氧基]丙基}氯乙酰胺(3);3与乙酸钾反应得到H2-受体拮抗剂罗沙替丁乙酸酯盐酸盐;3与伯胺反应合成了4个罗沙替丁的衍生物,再与草酸成盐得对应的草酸盐,其结构经1H NMR,IR和MS表征。更多还原

【Abstract】 N-{3-[3-(1-methylpiperidine)phenoxy]propyl}chloroacetamide(3) was synthesized by a three-step reaction from m-hydroxyl-benzaldehyde.Salt of roxatidine acetic ester with hydrochloric acid was prepared by the reaction of 3 with AcOK.Four roxatidine derivatives were synthesized by the reaction of 3 with primary amine and then with oxalic acid to obtain thier salts.The structures were confirmed by 1H NMR,IR and MS.更多还原

【关键词】罗沙替丁； H2-受体拮抗剂；苯甲醛；药物合成；
【Key words】 roxatidine； antiulcer agents； benzaldehyde； drug synthesis；

【文献出处】合成化学 ,Chinese Journal of Synthetic Chemistry , 编辑部邮箱 ,2008年03期

【分类号】TQ463.53
【被引频次】2
【下载频次】235

知网节下载

节点文献中：

本文链接的文献网络图示:

本文的引文网络

节点文献