【摘要】 目的探讨初诊的2型糖尿病(2-DM)患者体内的胰升糖素样肽-1(GLP-1)变化以及与血糖、C肽的关系。方法未接受降糖药物治疗的初诊2-DM患者27例为实验组,健康体检者31例作为对照组。采用酶联免疫吸附法(ELISA)检测空腹及早餐后2h血清GLP-1;采用放射免疫法(RIA)检测空腹及早餐后2h血清C肽;采用氧化酶法检测空腹及早餐后2h血浆血糖。结果两组间空腹及早餐后2hGLP-1、血糖、C肽均存在显著差异。GLP-1与血糖呈负相关,与C肽呈正相关。结论对于初诊2-DM患者来说,内源性GLP-1的分泌是低下的,刺激胰岛素分泌的作用也是低下的,倘若给予一定量的外源性的GLP-1,刺激胰岛素的分泌,就能起到降血糖作用。更多还原

【Abstract】 Objective To explore the variety of the serum GLP-1 in the type 2 diabetes mellitus (2-DM) of newly diagnosed and healthy man, and the association of GLP-1, C-peptide and the serum glucose. Methods 27 cases of 2-DM subjects of newly diagnosed who didn’t accept the therapy of hypoglycemic medicine were experimental group. 31 normal health people were as control group. To examine the limosis and 2h postprandial the serum GLP-1 by using the Enzyme-Linked-Immunosorbent Assay (ELISA), to examine the limosis and 2h postprandial the serum C-peptide by using radiological immunization assay (RIA), and to examine the limosis and 2h postprandial blood glucose by using oxidase methods. Results There were significantly differences in GLP-1、C-peptide and blood glucose for the limosis and 2h postprandial between in 2 groups. GLP-1 has correlated positively with C-peptide, and correlated negatively with the blood glucose.Conclusion For 2-DM patients of newly diagnosed, endocrine GLP-1’s secretion is in a low standard , and the function which stimulates insulin is also lowly. If give the extraneous GLP-1 to stimulates the secretion of insulin , it can reduce the blood glucose level .更多还原