【摘要】 目的:通过炎性因子的变化来探讨电视辅助胸腔镜技术(VAST)对胸外伤手术治疗的价值。方法:2004年6月-2006年6月本院收治胸外伤患者76例,随机分为VAST辅助手术组(简称VAST组)和常规开胸手术组(简称对照组),其中VAST组40例,对照组36例。对比检测患者手术前、手术后即刻、术后第1、2、3天的白介素2(IL-2)与白介素(IL-10)变化,并进行重复测量数据分析。结果:两组患者术后均恢复良好,无死亡病例。术前两组IL-2含量无统计学差异,手术后即刻、术后第1、2、3天VAST组IL-2含量(161.01±32.52,156.04±19.77,157.30±23.16,148.42±41.78)ng/L均小于对照组(P<0.05);两组IL-10含量在手术前及手术后即刻差异无统计学意义,但术后第1、2、3天VAST组IL-10含量(91.07±13.53,91.89±12.23,85.11±9.71)ng/L均大于对照组(P<0.05)。结论:VAST辅助开胸手术方法对胸外伤伤者创伤程度小于常规开胸手术。更多还原

【Abstract】 Objective: To explore the value of video-assisted thoracic surgery (VATS) for treatment of chest trauma based on the profiles of inflammatory cytokines. Methods:From June 2004 to June 2006, 76 victims from chest trauma received operations which included VATS and conventional open chest surgery randomly assigned to two groups (the VATS group, n=40; the control group, n=36). Serum IL-2 and IL-10 were determined respectively before operation, immediately after operation, at days 1 to 3 after operation, followed by repeated measures analysis. Results:The patients recovered uneventfully and no death was reported. While the levels of IL-2 did not differ statistically between the two groups before operation, immediately after operation and at days 1 to 3, VATS group showed lower levels of IL-2 (161.01±32.52, 156.04±19.77, 157.30±23.16 and 148.42±41.78)ng/L as compared with controls (P<0.05). Higher levels of IL-10 (91.07±13.53, 91.89±12.23, 85.11±9.71)ng/L were also shown in VATS group at days 1 to 3 (P<0.05) but not before and immediately after operation. Conclusion:VATS appears less invasive than traditional approach for patients with chest trauma.更多还原