【摘要】 口蹄疫是偶蹄动物的一种烈性传染病,可使世界范围内的畜牧业遭受严重的经济损失。该病的防控方法主要包括扑杀、销毁病畜及其同群动物,对疫区内其它易感畜群和受威胁区的易感动物立即紧急接种对应型号的口蹄疫疫苗,除此之外,还需要有一些新的紧急抗病毒策略来弥补疫苗的不足,从而为易感动物及未感染动物提供及时的保护,作者着重综述了抗口蹄疫病毒策略的研究进展,主要包括IFN的应用、反义技术的应用、RNA干扰技术的应用三方面内容。更多还原

【Abstract】 Foot-and-mouth disease(FMD) is one of the most highly contagious diseases which affects domestic cloven-hoofed animals.And the disease has debilitating effects,including weight loss,decrease in milk production,and loss of draught power,resulting in a loss in productivity for a considerable time.Current methods of disease control include inhibition of animal movement,slaughter of infected and in-contact susceptible animals,and vaccine inoculation.While current vaccine can induce complete protection by 7~10 days,in emergency outbreak situations it is imperative to block or reduce virus shedding as rapidly as possible to contain the outbreak,so some antiviral approach were needed to provide protection for sensitive animals and normal animals during the early of after vaccine inoculation.In this article,progress on antiviral approach of foot-and-mouth disease was reviewed,including IFN,antisense technology and RNA interference.更多还原