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乳化/内部凝胶化工艺制备海藻酸钙凝胶微球的研究

Preparation of calcium alginate gel beads by emulsion-internal gelation technology

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【作者】 林军章于炜婷徐小溪刘袖洞马小军

【Author】 LIN Jun-zhang1,2,YU Wei-ting1,XU Xiao-xi1,,LIU Xiu-dong3,MA Xiao-jun1 (1.Laboratory of Biomedical Material Engineering,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;2.Graduate School of the Chinese Academy of Sciences,Chinese Academy of Sciences,Beijing 100049,China;3.College of Environment and Chemical Engineering,Dalian University,Dalian 116622,China)

【机构】 中国科学院大连化学物理研究所生物医学材料工程组中国科学院研究生院大连大学环境与化学工程学院

【摘要】 从乳化/内部凝胶化制备海藻酸钙凝胶微球的机理入手,系统考察了制备工艺参数如油水比、表面活性剂添加量、碳酸钙添加量和冰乙酸添加量对海藻酸钙凝胶微球的球形度、粒径大小及分布、产率的影响规律。通过对该工艺参数的优化,能够制备出球形度良好,产率在85%以上,粒径分布均一的海藻酸钙凝胶微球。

【Abstract】 Based on the mechanism analysis of emulsification/internal gelation technology,the effects of technological parameters on the properties of calcium alginate gel beads were systematically studied in this paper.It was demonstrated that the technological parameters such as the oil/water ratio,the concentration of surfactant,the amount of calcium carbonate and the concentration of acetic acid had significant effect on the properties of gel beads.By optimizing parameters,the alginate gel beads with good sphericity,homogenous particle size and 85% yield were prepared by this technology.

【基金】 国家重点基础研究发展计划(973计划)资助项目(2007CB714305);国家自然科学基金资助项目(20736006);“十一五”国家科技支撑计划资助项目(2006BAD27B04);大连市青年科技人才基金资助项目(2007J23JH036)
  • 【文献出处】 功能材料 ,Journal of Functional Materials , 编辑部邮箱 ,2008年11期
  • 【分类号】TB34
  • 【被引频次】16
  • 【下载频次】713
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