【摘要】 以1,3-环己二酮为起始原料,经过3步合成,得到了适用于多种天然产物合成中的关键中间体3,3,7,7,9-五甲基-1,5-二氧螺[5.5]十一烷-8-酮。利用红外光谱、元素分析以及1H与13CNMR确定了目标化合物的准确结构;利用二维核磁共振技术1H-1HCOSY、NOESY、HMBC以及HSQC,对其1H和13CNMR进行了全归属,并得到了目标化合物的空间结构相关信息。更多还原

【Abstract】 Being recognized as a key intermediate in the synthesis of many kinds of natural products,3,3,7,7,9-pentamethyl-1,5-dioxaspiro[5.5]undecan-8-one was successfully synthesized and it was characterized by IR,MS,1H and 13C NMR.The chemical shifts of 1H and 13C NMR were fully assigned via several kinds of 2D NMR experiments such as 1H-1H COSY,NOESY,HMBC and HSQC.At the same time,the steric configuration of the title product was determined by NOESY.更多还原