【摘要】 目的:评价良、恶性骨病变的MSCT灌注成像特征。方法:34例经手术病理或细胞学穿刺证实的良、恶性骨病变患者,均行16排螺旋CT灌注扫描,分别测定血流量(BF),血容量(BV),平均通过时间(MTT)和表面通透性(PS)。结果:恶性组各项灌注值普遍高于良性组,良性组的BV,BF值分别为(2.0561±1.82)ml/100mg,(24.838±22.286)ml/(100mg.min),恶性组的BV,BF值分别为(75.049±61.305)ml/100mg,(413.09±397.98)ml/(100mg.min),两者差异有极显著性意义(P<0.01);良性组的PS值为(4.05±3.71)ml/(100mg.min),恶性组的PS值为(8.2154±5.0709)ml/(100mg.min),两者差异有显著性意义(P<0.05);而MTT值差异无显著性意义(P>0.05)。结论:MSCT灌注成像对良、恶性骨病变的诊断和鉴别诊断有重要的临床意义。更多还原

【Abstract】 Objective:To study the application and its characteristic role of multi-slice CT(MSCT)perfusion technique in the diagnosis and differential diagnosis of benign and malignant bone lesions.Methods:MSCT perfusion scans were performed in thirty-four cases with pathologically confirmed bone lesions(24 cases with malignant lesions and the remaining 10 with benign ones)and the measurements of blood flow(BF),blood volume(BV),mean transit time(MTT)and vascular permeability of surface(PS)of the lesions were statistically analyzed using a commercial software.Results:The four measurements of malignant bone lesions were all higher than those of the benign ones.The values of BV and BF of the benign lesions were(2.0561±1.82)ml/100mg and(24.838±22.286)ml/(100mg·min)respectively and those of the malignant ones were(75.049±61.305)ml/100mg and(413.09±397.98)ml/(100mg·min)respectively.There were very significant differences(P<0.01)in BV and BF between benign and malignant bone lesions.The PS of the benign bone lesion group was measured as(4.05±3.71)ml/(100mg·min)and that of the malignant group was measured as(8.2154±5.0709)ml/(100mg·min).Also,the statistical difference of PS between the benign and malignant groups showed significant(P<0.05).However,the MTT values of the benign and malignant bone lesions(10.190±9.0995s and 14.116±9.9047 respectively)demonstrated no statistical significance(P>0.05).Conclusion:MSCT perfusion was not only capable of demonstrating the blood supply details of benign or malignant bone lesions,but also providing the information concerning their nature of malignancy or benignancy.更多还原