【摘要】 目的:探讨了牙周病患者血清IL-8、IL-10、IL-18和M-CSF检测的临床意义。方法:应用放射免疫分析和酶联免疫法对55例牙周病患者进行了治疗前后血清IL-8、IL-10、IL-18和M-CSF水平检测,并与35名正常健康人作比较。结果:牙周病患者在治疗前血清IL-8、IL-10、IL-18和M-CSF水平均非常显著地高于正常人组(P<0.01),经治疗后一个月,与正常人组比较仍有显著性差异(P<0.05)。结论:细胞因子IL-8、IL-10、IL-18和M-CSF在牙周病的发生、发展过程中相互作用,观察其浓度的变化对探讨其发病机理、预防和指导用药均有重要价值。更多还原

【Abstract】 Objective To explore the significance of changes of serum IL-8,IL-10,IL-18 and M-CSF levels in patients with periodontitis.Methods Serum levels of IL-8,IL-10,M-CSF(with RIA) and IL-18(with ELISA) were measured in 55 patients with periodontitis both before and after treatment as well as in 35 controls.Results Before treatment,serum levels of IL-8,IL-10,IL-18 and M-CSF were significantly higher in the patients than those in the controls(P<0.01).After one month of treatment,the serum IL-8,IL-10,IL-18 and M-CSF levels decreased somewhat,but were still significantly higher than those in controls(P<0.05).Conclusion There was disturbance of immunomodulation in patients with periodontitis as expressed by the changes of several cytokines levels in the course of the diseases.更多还原