【摘要】 目的:探讨新生儿病房内采用单种抗生素治疗新生儿感染性疾病的可行性。方法:随机选取在广西壮族自治区妇幼保健院住院的新生儿115例,对入选病例均采用单种抗生素治疗,对所有病例均行无菌操作。结果:115例患儿经单种抗生素规律治疗后,除2例新生儿脐膨出术后感染外,其他疾病的血白细胞计数和C反应蛋白均发生明显变化,经统计学分析有显著差异(P<0.05,P<0.01);68例新生儿肺炎经1周治疗后,63例新生儿肺部炎症吸收好转,好转率92%;新生儿败血症患儿15例,血培养表皮葡萄球菌4例,金黄色葡萄球菌1例,大肠埃希菌2例,变形杆菌1例,经改用敏感抗生素治疗1周血培养阴性;脑脊液提示化脓性脑膜炎3例,选用透过血脑屏障的敏感药物治疗2周后复查脑脊液正常。结论:在合理安排床位、净化病房环境和无菌操作前提下,病房内采用敏感单种抗生素是可行的,避免了抗生素滥用,不会延长住院时间。更多还原

【Abstract】 Objective: To explore the possibilities of treating infection diseases by adopting single antibiotics in neonatal wards.Methods:115 cases of neonates were randomly selected from neonatal wards of Guangxi Zhuang municipality maternity and children healthy hospital and treated with single antibiotics and germfree operation.Results:115 infection diseases treated with single antibiotics,with exception of 2 cases of postoperative infection of acromphalus,had obvious changes in their white blood cell(WBC) and C-reactive protein(CRP)(P<0.05).One week after the treatment,63 cases of neonatal pneumonia were with a recovery rate of 92%.Blood culture indicated there were 4 cases of staphylococcus epidermidis,1 case of staphylococcus aureus,2 cases of Escherichia coli and 1 of bacillus proteus,showing negative as a result of blood culture after one week of administration of sensitive antibiotics;3 cases of purulent meningitis revealed by CSF were treated with sensitive antibiotics permeating blood-brain barrier for 2 weeks and the result of CSF presented negative.Conclusions:Under reasonable sickbed arrangement,decontaminated environment and germfree operation,it is feasible to use senstive single antibiotics to treat neonatal infection diseases,which can avoid misuse of antibiotics,moreover,the hospitalization won’t be prolonged.更多还原