【摘要】 目的探讨无创通气在慢性阻塞性肺疾病(COPD)急性发作伴呼吸衰竭中的应用。方法将50例COPD急性加重合并Ⅱ型呼吸衰竭患者随机分为对照组和实验组,每组25例。对照组用常规药物治疗,实验组用常规药物加无创正压通气治疗。结果两组患者治疗前的基础情况和血气指标差异无统计学意义(P>0.05)。治疗后实验组呼吸频率(RR)、心率(HR)、动脉血pH、氧分压(PaO2)、二氧化碳分压(PaCO2)均明显改善(P<0.05),但实验组与对照组比较,治疗后PaO2上升更明显(P<0.01),PaCO2下降更明显(P<0.01)。治疗48 h后,实验组和对照组呼吸困难明显缓解的人数分别为22例和13例(P<0.05)。实验组和对照组平均住院日分别为(12±5)d和(18±6)d(P<0.01)。结论无创通气治疗COPD急性发作伴呼吸衰竭较仅用常规药物治疗能更快地缓解临床症状,提高PaO2和降低PaCO2。更多还原

【Abstract】 Objective To observe the effect of non-invasive ventilation(NIV) in acute respiratory failure with chronic obstructive pulmonary disease(COPD).Methods Fifty patients were randomizedly received conventional medical therapy(control group)or conventional medical therapy plus noninvasive ventilation(trial group).Results Two groups had similar clinical characteristics and gas exchange profile before treatment.After treatment the respiratory rate,heart rate,pH,PaO2,and PaCO2 improved significantly compared with baseline in trial group(P<0.05).But improvements in PaO2,PaCO2 and dyspena in trial group were much better than those in control group(P<0.01).The average duration of hospitalization was shorter in trial group(12±5)days than that in control group(18±6)days(P<0.01).Conclusion The use of non-invasive ventilation in COPD patients with exacerbated respiratory failure can rapidly improve clinical symptoms and arterial blood gases.更多还原