【摘要】 禽白血病病毒(Avian leukosis virus,ALV)入侵宿主细胞的关键是病毒囊膜与宿主细胞膜的融合,ALV在此过程中采用病毒-宿主细胞膜融合机制,这一机制的关键是病毒与细胞受体结合后跨膜蛋白一系列构象的变化。此外,ALV入侵宿主细胞后会引起严重的免疫抑制,继而引发肿瘤的产生。在对一些与ALV有相同感染机制的病毒的研究中发现,引起免疫抑制的关键区也是跨膜蛋白。因此进一步在分子水平上深入研究跨膜蛋白有助于正确认识病毒侵染的本质,做到更为有效的预防与治疗ALV感染。更多还原

【Abstract】 The key point of Avian leukosis virus(ALV) invading host cell is the fusion of virus envelope and host cell membrane.According to some report,ALV adopts virus-host cell membrane fusion mechanism in entry process and the subsequent conformation change of transmembrane protein after virus binding to cell receptor playing an important role in this mechanism.In addition,after invading host cell,ALV can trigger serious immunosuppression which may induce tumors.In the research of some viruses which have the same infection mechanism as ALV informing us it is also the transmembrane protein that educing decisive role in immunosuppression.Therefore,the further study of transmembrane protein on the molecular level can help us recognize the invading essence and prevent or heal the infection of ALV effectively.更多还原