【摘要】 目的:观察重型肝炎患者在血浆置换治疗前后血清IL-2,IL-6,TGFβ1,TNF-α,sFas及IFN-α水平的变化.方法:采用血浆置换技术治疗重型肝炎58例,用ELISA法测定治疗前后血清中IL-2,IL-6,TGFβ1,TNF-α,sFas及IFN-α的水平,并与20例正常献血员进行对照.结果:治疗组患者治疗前血清IL-2,IFN-α水平明显低于对照组(P<0.01),IL-6,TGFβ1,TNF-α及sFas水平明显高于对照组(P<0.01);治疗后血清IL-2,IFN-α水平较治疗前明显升高(P<0.01),IL-6,TGFβ1,TNF-α及sFas水平较治疗前明显下降(P<0.01).结论:血浆置换对IL-6,TGFβ1,TNF-α及sFas有较好的清除作用,可使IL-2和IFN-α水平升高,能减轻重型肝炎时肝细胞的损伤,提高重型肝炎的存活率.更多还原

【Abstract】 AIM:To investigate serum IL-2,IL-6,TGF β1,TNF-α,sFas,IFN-α levels in patients with severe hepatitis before and after plasma exchange treatment.METHODS:Plasma exchange technology was ased to treat 58 cases with severe hepatitis.Serum IL-2,IL-6,TGF β1,TNF-α,sFas,IFN-α levels were deter mined by ELISA before and after treatment,which were compared with 20 normal blood donors.RESULTS:Before treatment,serum IL-2,IFN-α levels were significantly lower(P<0.01),and IL-6,TGF β1,TNF-α,sFas levels were significantly higher in treatment group than in control group(P<0.001).After treatment,serum IL-2,IFN-α levels increased significantly(P<0.01),and IL-6,TGF β1,TNF-α,sFas levels decreased significantly(P< 0.01).CONCLUSION:Plasma exchange play an important role in removing IL-6,TGF β1,TNF-α,sFas,which can increase IL-2,IFN-α level,reduce liver cell damage in severe hepatitis,and improve the survival rate of severe hepatitis.更多还原