【摘要】 目的:探讨治疗开角型青光眼的新术式经眼内巩膜切开术,对房水流畅系数的影响,以评价该手术的有效性.方法:用Krebs-Ringers液相继以2.5,5,7.5μL/min不同的灌注速度,灌注16只离体猪眼前房后,8只眼行经眼内巩膜切开术,其他8眼为假手术组,分别于手术前后在不同的灌注速度下测定眼内压,根据Goldmann公式:C=ΔI/ΔIOP得出房水流畅系数.结果:手术后于不同灌注速度下的房水流畅系数经眼内巩膜切开组,较术前增加,房水阻力下降,与术前相比较差异有统计学意义(P<0.05);经眼内巩膜切开组在术后以5,7.5μL/min灌注时的房水流畅系数和房水阻力与假手术组术后同一灌注速度时相比较差异亦有统计学意义(P<0.05).假手术组房水流畅系数及房水阻力手术前后差异均无统计学意义(P>0.05).结论:经眼内巩膜切开术通过增加房水流畅系数能够有效控制眼内压.更多还原

【Abstract】 AIM:To investigate the influence of the sclero-thalamotomy ab interno,a new anti open-angle glaucoma surgery,on aqueous outflow facility in vitro and evaluate the efficacy of the intervention.METHODS:The anterior chambers of 16 enucleated eyes were perfused with Krebs-Ringer’s solution successively at different perfusion rates(2.5,5,7.5 μL/min).Sclero-thalamotomy ab interno was then performed on 8 eyes and sham operation on another 8 eyes,and the intraocular pressure was measured before and after operations at different perfusion rates.The aqueous outflow facility was assessed according to Goldmann equation:C=ΔI/ΔIOP.RESULTS:Obvious increase of aqueous outflow facility and the decrease of aqueous outflow resis-tance were presented after sclerothalamotomy ab interno at dif-ferent perfusion rates,and there was significant difference between pre-and post-operation(P<0.05),and there was also difference between post-sclerothalamotomy ab interno and post-sham surgery at perfusion rates of 5,7.5 μL/min(P<0.05).No difference was seen both in aqueous outflow facility and out-flow resistance before and after the sham surgery(P>0.05).CONCLUSION:This study demonstrates that sclerothalamotomy ab interno is effective in controlling the intraocular pressure by increasing aqueous outflow facility.更多还原