【摘要】 目的:观察多西他赛联合顺铂(或卡铂)方案对蒽环类耐药的晚期乳腺癌患者的临床疗效及毒副作用.方法:40例蒽环类耐药的晚期乳腺癌患者,采用多西他赛75mg/m2静滴,第1日,给予顺铂30mg/m2静滴,第1~3日(或卡铂按AUC5计算,静滴,第1日),28d为1周期,2周期后评价疗效,有效者化疗4周期以上.结果:40例中完全缓解4例,部分缓解18例,稳定9例,进展9例,总有效率为55%(22/40).主要毒性反应为恶心、呕吐、骨髓抑制.结论:多西他赛联合顺铂(或卡铂)方案治疗蒽环类耐药的晚期乳腺癌疗效较好,不良反应可耐受.更多还原

【Abstract】 AIM:To observe the curative effect and toxicity of docetaxel plus cisplatin in advanced breast cancer patients who were drug fast in using anthracene nucleus drugs.METHODS: Forty patients received docetaxel 75 mg/m2 on day 1 and cisplatin 30 mg/m2 on day 1-3, or carboplatin(AUC=5) on day 1 of every 28 d. Every patient was administered not less than 2 cycles.The effective patients received at least 4 cycles. RESULTS: Complete response was achieved in 4 cases, Partial response in 18 cases, Static disease in 9 cases, Progressive disease in 9 cases, and the overall response rate was 55% (22/40).The main adverse effects included nausea, vomiting and myelosuppression. CONCLUSION: The regimen based on docetaxel is effective in the treatment of patients with advanced breast cancer and toxicities are tolerable.更多还原