【摘要】 目的:探讨75岁以上原发性肝癌(PHC)患者行经导管肝动脉化疗栓塞(TACE)的安全性.方法:对我科2001-01/2007-01首次行TACE的3879例肝癌患者进行回顾性分析,将其中年龄≥75岁的高龄PHC患者403例归入A组,同期年龄≤40岁的PHC患者759例归入B组.对两组患者术中异常情况、术后严重并发症发生率、围介入手术期的死亡率进行比较.结果:A,B组的术中异常情况发生率分别为40.9%,7.5%,差异有统计学意义(P<0.05);A,B组的术后严重并发症发生率分别为9.7%,1.8%,差异有统计学意义(P<0.05);A,B组围介入手术期死亡率分别为0.7%,0.5%,无显著性差异.结论:高龄PHC患者TACE术中异常情况、术后严重并发症发生几率高.在做好充分的术前准备、术中术后密切监测生命体征、及时正确对症处理异常情况前提下,行TACE术是安全的.更多还原

【Abstract】 AIM: To evaluate the safety of transcatheter arterial chemoembolization (TACE) for primary hepatic carcinoma(PHC) in the elderly patients(≥75 years old). METHODS: We retrospectively analysed 3879 cases of liver cancer who were treated with TACE for the first time from January 2001 to January 2007. Among them, 403 elder PHC patients(≥75 years old) were classified into group A and 759(≤40 years old)patients were classified into group B. The data of abnormal occurrence rate in TACE, severe complication rate post-TACE and perioperative death rate of the two groups were compared. RESULTS: Abnormal occurrence rate in TACE was 40.9% in group A, and 7.5% in group B. There was remarkable difference between the two groups (P<0.05). Severe complication rate post-TACE was 9.7% in group A, and 1.8% in group B. There was remarkable difference between the two groups (P<0.05). Perioperative death rate was 0.7% in group A,and 0.5% in group B. There was no remarkable difference between the two groups (P>0.05). CONCLUSION: Abnormal occurrence rate in TACE and severe complication rate post-TACE are high in elder PHC patients. TACE is safe in the elderlies under precondition that preparation is made sufficiently before TACE, vital signs are monitored closely in TACE and post-TACE, and abnormal occurrence is treated promptly and correctly.更多还原