【摘要】 [目的]探讨妊娠糖尿病患者抵抗素水平的改变及与胰岛素抵抗(IR)的关系。[方法]对42例妊娠糖尿病患者(gestational diabetes mellitus,GDM)、50例糖耐量正常的孕妇,进行葡萄糖耐量试验(OGTT)、胰岛素释放试验(IRT),并测定血清抵抗素水平,同时稳态模型(HOMA)计算胰岛素抵抗指数(HOMA-IR),分析血清抵抗素与GDM患者IR的关系。[结果](1)GDM组抵抗素水平为(13.7±3.4)μg/L,对照组为(10.2±2.6)μg/L,两组比较差异有统计学意义(P<0.05)。(2)GDM组HOMA-IR为(3.0+1.1),对照组为(2.6+0.7),两组比较差异有统计学意义(P<0.05)。(3)GDM组Homa-IR与孕前体重指数(BMI)、空腹胰岛素、抵抗素呈正相关(P<0.05或P<0.01)。[结论]GDM患者血清抵抗素水平明显升高,且与GDM患者IR密切相关。更多还原

【Abstract】 [Objective] To investigate the levels of resistin in patients with gestational diabetes mellitus(GDM) [Methods] Resistin was determined in 42 patients with GDM and 50 control subjects.the insulin resistance index(HOMA-IR) was calculated at the same time.[Results](1) In GDM group,The meams of resistin,HOMA-IR were(13.7±3.4)μg/L,(3.0+1.1),in the control subjects,The meams of resistin,HOMA-IR were(10.2±2.6)μg/L,(2.6+0.7),(P<0.05);(2) In the group of GDM,Pearson correlation analysis indicated that Homa-IR were positively correlated to resistin.[Conclusion] Resistin was highter in GDM compared with those control subjects,resistin might play an important role in pathogensis of insulin resistance.更多还原