【摘要】 [目的]评价吡柔比星(THP)膀胱灌注预防膀胱肿瘤TURBT术后复发的疗效和安全性。[方法]1999年11月~2003年10月,膀胱肿瘤TURBT术后患者63例,术后接受THP30 mg膀胱灌注治疗,随访12~53个月。[结果]膀胱癌TURBT术后THP膀胱灌注,术后1年未复发率89.8%,术后2年未复发率83.1%,术后3年未复发率76.3%;膀胱灌注THP副反应发生率为28.57%。[结论]应用THP30 mg/50 mL(600μg/mL),TURBT术后尽早膀胱灌注,膀胱内保留30 min,采用为期1年的短期疗程,对于预防膀胱肿瘤TURBT术后复发有较好的疗效。更多还原

【Abstract】 [Objective] To evaluate the effectiveness and safety of intravesical instillation of THP after transurethral resection of bladder cancer(TURBT).[Methods] From Nov.1999 to Oct.2003,a total of 63 patients were treated with intravesical instillation of THP after TURBT,the patients were followed up by cystscopy for 12~53 months.[Results] The non-recurrence rates at 1,2 and 3 years were 89.8%,83.1% and 76.3%,respectively.The side effect rate was 28.57%.[Conclusions] Our findings demonstrated that short-term(1 year),30 minutes instillation intensive intravesical instillation of THP 30 mg/50 mL(600 μg/mL) after TURBT was a safe and effective therapy.更多还原