【摘要】 目的:通过观察原发性商血压(EH)患者血浆中脑利钠肽(BNP)水平的变化,探讨其与EH患者24小时血压昼夜变化及左室肥厚(LVH)的关系。方法:对EH患者93例,对照组20例行24h动态血压监测,采用放射免疫分析法测定血浆BNP含量;同时测定其左窒质量指数(LVMI)。结果:(1)EH患者血浆BNP水平明显高于对照组(P<0.01);(2)与杓型组相比,非杓型组BNP水平升高更为明显(P<0.05);(3)两组EH中伴左室肥厚的患者血浆BNP水平无明显差异(P>0.05);(4)杓型EH患者血浆BNP水平与24小时平均脉压(24hPP)成正相关(r=0.56,P<0.01),非杓型EH患者则无明显相关性(P>0.05)。结论血浆BNP水平与EH患者血压昼夜变化异常和左室肥厚有关。更多还原

【Abstract】 To investigate the relationship of B-Type Natriuretic Peptide Level and the diurnal rhythm of blood pres- sure and left ventricular hypertrophy for essential hypertension patients.Methods:Ambulatory BP monitoring(ABPM)for 24 hours was performed in ninety-three patients with essential hypertension and twenty control subjects.Plasma BNP level in subjects was measured using radioimmunoassay method,left ventricular hypertrophy were measured too.Results:Plasma BNP level was higher in patients with hypertension than that in control group(P<0.01).Compared with dippers,nondippers had a higher BNP plasma level(P<0.05).Among the two types of essential hypertension,patients with left ventrieular hypertrophy had the same BNP level(P>0.05). There was significant correlation between logarithmic-transformed plasma BNP level(log BNP)and 24 hours mean pulse pressure in dippers(r=0.56,P<0.01),but not in nondippers(P>0.05).Conclusion:Plasma BNP level was clinically useful for the early i- dentification of hypertensive patients who had abnormal circadian BP variability and left ventricular hypertrophy.更多还原